In the world of health and wellness, buzzwords come and go, but some stand the test of time due to the potent benefits they offer. One such enduring term is “adaptogens” – natural substances celebrated for their stress-busting properties and their potential to promote overall well-being. But what exactly are adaptogens? Where do they come from, and how can they be integrated into a daily health and fitness routine?
In this article, we delve into the world of adaptogens, exploring their origins, the diverse variety of herbs, roots, and botanicals in this category, and the scientific research supporting their use. We will look into their potential benefits, mechanisms of action, and how they differentiate from regular food substances. We will also navigate the potential side effects and provide insights into safe usage.
Aimed particularly at health and wellness coaches, this piece is designed to arm you with an informed perspective on adaptogens. The goal is not to endorse the prescription of supplements – as that generally lies outside the scope of practice for coaches – but to provide the tools needed to understand, educate, and guide clients who might be interested in or curious about these natural substances.
Dive in as we unravel the science and potential applications of adaptogens, equipping you with a nuanced understanding of this cutting-edge topic to enhance your coaching toolbox.
What Are Adaptogens?
Adaptogens are a unique class of herbs used in traditional medicine, celebrated for their ability to help the body cope with stress. The term ‘adaptogen’ was coined by Russian scientist N.V. Lazarev in 1947 to describe substances that could increase nonspecific resistance to stress.
Adaptogens work at the molecular level by regulating a stable balance in the hypothalamic-pituitary-adrenal (HPA) axis, which is the primary stress response system of the body. Furthermore, they interact with key molecular stress response pathways, enhancing the body’s resilience to stress, fatigue, and anxiety without disturbing normal biological functions.
Popular adaptogens include Ashwagandha, Rhodiola Rosea, and Ginseng. While Ashwagandha has been reported to improve stress resistance, vitality, and cognitive performance, Rhodiola Rosea helps combat fatigue, improve mood, and boost cognitive function. Ginseng is praised for its anti-fatigue properties and for enhancing mental performance under stress.
Though additional research is needed to understand the full potential and mechanism of adaptogens, their increasing popularity in the wellness industry reflects their potential to improve overall well-being and resilience in the face of stress.
What is the History of Adaptogens?
Adaptogens have a rich history that predates the coining of the term itself. The herbs now classified as adaptogens have been used for thousands of years across various cultures, with a primary emphasis on enhancing the body’s ability to cope with stress and promote overall well-being.
These healing herbs have roots in traditional medicinal systems, such as Ayurveda in India and Traditional Chinese Medicine (TCM) in China. For instance, the Ashwagandha, also known as “Indian ginseng,” has been a cornerstone of Ayurveda for over 3,000 years, utilized for its restorative and rejuvenating properties. Similarly, Ginseng, a staple in TCM, has been used for centuries to strengthen qi, the body’s vital energy, and to promote resistance against stress-related disorders.
However, as mentioned above, the term ‘adaptogen’ was introduced in a biomedical context by the Russian scientist N.V. Lazarev in 1947, representing substances that could enhance the body’s nonspecific resistance to stress. The concept was further developed by Russian scientists Israel Brekhman and Nikolai Dardymov in the 1960s, who established specific criteria for adaptogens.
So, while the notion of adaptogens seems like a discovery within the Western biomedical model, it’s more of a modern categorization or recognition of the value of these ancient herbs and their roles in fostering health and resilience.
What Herbs, Roots, and Botanicals Are Adaptogens?
Adaptogens can be herbs, roots, or other botanical substances. ‘Herbs’ typically refer to the leafy green parts of a plant, while ‘roots’ are the underground parts. ‘Botanicals,’ a broader term, encompasses any part of a plant used for its medicinal or therapeutic properties, including herbs, roots, flowers, seeds, bark, or other plant parts. Now, let’s explore some examples of adaptogenic herbs, roots, and botanicals.
- Ashwagandha (Withania somnifera): This herb, used in Ayurveda, is known for its potent stress-combating properties. A study by Chandrasekhar, Kapoor, and Anishetty demonstrated that Ashwagandha significantly reduced stress and anxiety in adults when compared to a placebo.
- Rhodiola Rosea (root): This root is native to cold regions like the Arctic and the mountains of Central Asia. It has shown promise in alleviating mental and physical fatigue, with a review by Ishaque, Shamseer, Bukutu, & Vohra providing evidence for its effectiveness in reducing stress-related fatigue.
- Ginseng (Panax ginseng): Both the roots of American Ginseng (Panax quinquefolius) and Asian Ginseng (Panax ginseng) are used for their adaptogenic properties. Reay, Kennedy, & Scholey found that ginseng improved cognitive performance and reduced fatigue during mentally demanding tasks.
- Holy Basil (Ocimum sanctum): Also known as tulsi, it is an adaptogenic herb used in Ayurveda. Cohen reported that holy basil could reduce stress, anxiety, and depression and improve sleep.
- Schisandra (Schisandra chinensis): This botanical comes from a fruit-bearing vine native to East Asia. It has demonstrated properties for improving endurance, mental performance, and working capacity.
- Cordyceps (Cordyceps sinensis): This fungus, traditionally found in the mountainous regions of China, has been used for its energy-enhancing and anti-fatigue effects. A study by Hirsch & Suh found that supplementation with cordyceps could potentially improve exercise performance and reduce fatigue.
- Eleuthero (Eleutherococcus senticosus): Commonly referred to as Siberian ginseng, this root was traditionally used in Chinese medicine. Kuo, Chen, & Shieh found it to have antioxidant properties and potential effects on endurance performance.
- Maca (Lepidium meyenii): This root, native to the Andes of Peru, has been found to have mood-enhancing and anti-depressant effects. A study by Stojanovska, Law, Lai, Chung, Nelson, Day, Haines, & Xie demonstrated maca’s potential to reduce psychological symptoms, including anxiety and depression.
- Reishi (Ganoderma lucidum): This mushroom has been used for thousands of years in Asian cultures to support immune health. Wachtel-Galor, Yuen, Buswell, & Benzie found that reishi has potential benefits in modulating the immune system.
- Astragalus (Astragalus membranaceus): This root, used in traditional Chinese medicine, is known for its immune-boosting properties and potential benefits in heart health. Auyeung, Han, Ko noted astragalus as a promising cardio-protective agent.
- Licorice Root (Glycyrrhiza glabra): This root has been traditionally used for various ailments, including digestive issues and adrenal support. Asl and Hosseinzadeh provide a comprehensive review of its anti-inflammatory, immune-modulatory, and antiviral benefits.
- Gotu Kola (Centella asiatica): Used in Ayurveda and traditional Chinese medicine, this herb has been associated with improved cognitive function. Wattanathorn et al. found that it has the potential to enhance memory and nerve function.
- Moringa (Moringa oleifera): This plant, native to the Himalayan regions, has been recognized for its rich nutritional profile and potential health benefits. Stohs and Hartman reported its antioxidant, anti-inflammatory, and tissue-protective properties.
- Shatavari (Asparagus racemosus): A staple in Ayurveda, this herb is known for its potential benefits for female reproductive health. A review by Alok et al. found it to have anti-inflammatory, immunomodulatory, and antioxidant properties.
- Bacopa (Bacopa monnieri): Another staple of Ayurveda, bacopa is traditionally used for improving memory and reducing anxiety. A study by Calabrese et al. indicated that bacopa has potential memory-enhancing effects.
- Turmeric (Curcuma longa): Known for its vibrant color and use in cooking, this root has substantial research supporting its anti-inflammatory effects, with Jurenka noting it as a potential treatment for inflammatory and degenerative eye conditions.
- Chaga (Inonotus obliquus): This mushroom, found on birch trees in colder climates, is known for its antioxidant properties. A review by Cui, Kim, & Park found chaga could inhibit oxidative DNA damage.
- Suma (Pfaffia paniculata): This root, also known as Brazilian ginseng, is traditionally used for its potential to restore and enhance physical performance. Aquino, Conti, Simoni, & Canini reported suma’s immunostimulating properties.
- Mushroom Blend (various species): There are several varieties of mushrooms (like reishi, cordyceps, chaga, and lion’s mane) that are commonly used as adaptogens. Each mushroom species has unique properties; for instance, reishi is known for its immune-modulating effects, while lion’s mane might improve cognitive function.
- Sea Buckthorn (Hippophae rhamnoides): This plant, native to Europe and Asia, has berries that are full of nutrients and antioxidants. It is used traditionally to promote overall health and treat various ailments. A review by Olas highlights sea buckthorn’s potential as an adaptogen with antioxidant, anti-inflammatory, and anticancer properties.
As with any supplement or health practice, it’s important to consult with a healthcare provider before starting any new regimen, as adaptogens can interact with medications or cause side effects in certain populations.
What Are the Benefits of Adaptogens?
Adaptogens offer a myriad of benefits due to their unique ability to help the body adapt to stress, promoting overall well-being. Here are some of the key benefits of adaptogens:
Improved Stress Management
In the face of stress, the body’s response involves a series of biochemical reactions that can impact overall health. Adaptogens help the body maintain balance during stressful periods by interacting with the hypothalamic-pituitary-adrenal (HPA) axis, the body’s central stress response system. Additionally, adaptogens modulate the body’s stress response, supporting the adrenal glands, which manage hormones responsible for the physiological stress response. For instance, ashwagandha has been studied for its ability to lower levels of the stress hormone cortisol.
Increased Energy and Reduced Fatigue
In today’s fast-paced society, chronic fatigue is a common issue. Adaptogens can help mitigate feelings of fatigue and enhance energy levels. Rhodiola rosea, for example, has been shown to improve symptoms of burnout, which often includes physical and mental fatigue. It can do this by increasing the body’s capacity to utilize oxygen, particularly under conditions of physical strain or high-altitude stress. This can enhance energy production and resistance to fatigue.
Improved Mental Performance
The brain’s capacity to perform cognitive tasks can be enhanced by certain adaptogens. For example, Bacopa monnieri, commonly used in Ayurvedic medicine, has been shown to improve various aspects of cognitive function, including memory, attention, and the speed of processing information. It increases the expression of certain proteins involved in forming new synapses, enhancing learning and memory.
Improved Mood and Mental Health
Some adaptogens have been associated with improved mood and mental health outcomes, potentially acting as a supplemental treatment for mood disorders like depression and anxiety. Maca, in particular, has been studied for its mood-enhancing properties and potential antidepressant effects. While the mechanisms are not entirely understood, it may do this by balancing levels of monoamine neurotransmitters, which include serotonin, norepinephrine, and dopamine.
Immune System Support
Adaptogens can support the immune system’s function, helping to protect against disease by modulating the immune system by affecting various immune cells, cytokines, and other proteins involved in the immune response. Reishi mushroom, for instance, has been studied for its immunomodulatory effects, potentially supporting the immune system’s function and enhancing the body’s resistance to certain illnesses.
Anti-Inflammatory Properties
Inflammation is the body’s response to injury or infection, but chronic inflammation can lead to various health problems. Turmeric and its primary active compound, curcumin, exert anti-inflammatory effects possibly by down-regulating the activity of cyclooxygenase-2 (COX-2), lipoxygenase, and inducible nitric oxide synthase (iNOS) enzymes; inhibiting the production of inflammatory cytokines; and inducing the activity of heat shock proteins, all of which play a role in the inflammatory process.
Antioxidant Effects
Oxidative stress, caused by an imbalance of free radicals and antioxidants in the body, can lead to cell damage and has been linked to various chronic conditions. Some adaptogens contain bioactive compounds that can neutralize free radicals, reduce oxidative stress, and prevent cellular damage. For example, Chaga mushroom contains a high amount of antioxidants, which can scavenge free radicals and reduce oxidative stress, thereby protecting cellular components from oxidative damage.
As mentioned above, while these benefits are supported by research, the effects can vary from person to person. Always consult a healthcare provider before beginning any new supplement regimen, as some adaptogens can interact with certain medications or health conditions.
Adaptogenic Foods: Can Foods Be Adaptogenic?
The concept of “adaptogenic foods” has been emerging along with interest in adaptogenic herbs. While adaptogens are typically thought of as certain herbs, roots, and botanicals, the basic idea behind them – substances that help the body adapt to stress and maintain homeostasis – could theoretically apply to certain foods as well.
An adaptogenic food, in this context, is a nutrient-dense food that supports overall health and helps balance the response to stress. They can be thought of as foods that have a normalizing effect on body processes and can help the body adapt to different stressors, whether they are physical, chemical, or biological.
Take, for instance, fatty fish like salmon and mackerel. They are rich in omega-3 fatty acids, which have been found to modulate the body’s stress response and lower inflammation levels. Berries, which are packed with antioxidants, can also reduce oxidative stress and inflammation. Foods like leafy green vegetables and seeds are rich in magnesium, a mineral that plays a critical role in the body’s response to stress.
Fermented foods like yogurt and sauerkraut could also be considered adaptogenic, as they may contain probiotics and prebiotics that support gut health. There’s increasing evidence that the gut microbiota can impact the body’s stress response system, with healthier gut microbiota associated with a healthier stress response.
That being said, while there’s a growing interest in the concept of adaptogenic foods, it’s important to note that the scientific research in this area is still in its early stages. The term “adaptogen” is not yet widely used to refer to foods, and more research is needed to establish specific foods’ adaptogenic properties.
Therefore, while certain foods may share similar properties to adaptogens (in terms of stress response modulation, anti-inflammatory properties, and antioxidant effects), it’s crucial to continue consuming a balanced, varied diet that includes plenty of fruits, vegetables, lean proteins, and whole grains for overall health.
Risks and Side Effects of Adaptogens
While adaptogens are generally recognized as safe and have been used for centuries in traditional medicine, they are not devoid of side effects. Just as they can interact positively with the body, they can also have adverse effects, particularly if taken incorrectly or in excessive amounts. The side effects vary between different adaptogens and can also depend on the individual’s current health status, dosage, and duration of use.
For instance, Panax ginseng, one of the most commonly used adaptogens, may cause side effects such as insomnia, gastrointestinal issues, and headaches in some individuals. Ashwagandha, despite its numerous health benefits, can cause mild side effects like drowsiness, upset stomach, and diarrhea, especially at higher doses. Similarly, Rhodiola rosea may lead to a dry mouth, dizziness, and increased salivation in some people.
It’s also important to note that some adaptogens can interact with medications. For example, St. John’s Wort, another popular adaptogen, can interfere with the effectiveness of prescription medications, including certain antidepressants, birth control pills, and anticoagulants.
Pregnant or breastfeeding women, children, people taking medication, and those with certain health conditions such as liver disease or high blood pressure should use adaptogens with caution and under the guidance of a healthcare professional with knowledge and experience in natural medicine and supplements.
Moreover, the quality and purity of adaptogenic supplements can vary, and some may contain contaminants or not deliver the promised levels of active ingredients, underscoring the importance of choosing products from reputable suppliers.
While adaptogens can offer a wide range of health benefits, they should be used responsibly and with a full understanding of potential side effects. It’s always a good idea to consult with a healthcare provider before starting any new supplement regimen, including adaptogens.
How to Safely Add Adaptogens to Your Daily Regimen
The incorporation of adaptogens into your daily routine can potentially offer many health benefits, but it’s important to do so safely. Here are some guidelines for safely adding adaptogens to your regimen:
1. Consult a Healthcare Provider.
Before you start any new supplement regimen, including adaptogens, consult a healthcare provider. This is particularly critical if you have any existing health conditions or if you’re taking any medication, as certain adaptogens may interact with them. Your healthcare provider can help determine which adaptogens are right for you and advise on appropriate dosages.
2. Start with a Low Dosage.
When you begin taking a new adaptogen, it’s generally recommended to start with a lower dosage and gradually increase it. This allows your body to adjust to the new supplement and makes it easier to identify any potential side effects.
3. Follow Dosage Instructions.
Always follow the dosage instructions on the product label or those provided by your healthcare provider. Overconsumption of adaptogens could potentially lead to adverse side effects.
4. Choose High-Quality Products.
The quality and purity of adaptogenic supplements can vary. Therefore, it’s essential to choose products from reputable manufacturers who perform quality testing. Look for products that have third-party testing to ensure they don’t contain contaminants.
5. Listen to Your Body.
Pay attention to how your body reacts when you start taking an adaptogen. If you experience side effects, stop taking the adaptogen and consult your healthcare provider.
—
Adaptogens may be a beneficial addition to your daily regimen when used correctly. Always remember to consult with a healthcare provider and listen to your body’s responses to ensure a safe and effective experience with these powerful plants.
Natural Adaptogenic Botanicals vs. Supplements: What’s the Difference?
While adaptogens are available in various forms, including their natural form (whole food or herbs) and in dietary supplements (capsules, powders, or tinctures), there are significant differences to consider between the two.
Concentration of Active Compounds
Dietary supplements often contain concentrated forms of the active compounds found in adaptogenic botanicals, which can make them more potent than the natural form. Supplements are designed to deliver a high level of bioactive compounds, which can ensure that you get a consistent dosage of the adaptogen. On the other hand, the concentration of active compounds in natural forms can vary depending on many factors like the plant’s growth conditions and how it is prepared or cooked.
Absorption and Bioavailability
The body’s ability to absorb and utilize adaptogens, known as bioavailability, may differ between natural forms and supplements. Some studies suggest that consuming adaptogens in their natural form may improve their bioavailability due to the presence of other natural compounds that promote absorption.
Co-Occurring Compounds
Natural forms of adaptogenic botanicals often contain a variety of additional beneficial compounds such as fibers, vitamins, and other phytonutrients that can provide added health benefits. Supplements, on the other hand, are often isolated or synthesized versions of the active compounds and may not contain these additional beneficial substances.
Risk of Contaminants
Dietary supplements are not as tightly regulated as prescription drugs, which can lead to inconsistencies in quality, potency, and safety. Contaminants, such as heavy metals or other toxins, have been found in some adaptogenic supplements. In contrast, consuming adaptogens in their natural form, especially if organically grown, may reduce the risk of exposure to such contaminants.
Both natural forms and supplements of adaptogenic botanicals can provide health benefits, but they come with their respective advantages and challenges. It is essential to consult with a healthcare provider before starting any new supplement regimen to ensure safety and efficacy.
How Long Does It Take to See Benefits of Adaptogens?
As with many natural substances, the effects of adaptogens are not typically immediate and require consistent use over time. The duration it takes to see the benefits of adaptogens can vary widely based on several factors, including the type of adaptogen, the dosage, the individual’s health status, and lifestyle factors such as diet and stress levels.
Type of Adaptogen
Different adaptogens have different primary actions and may take varying amounts of time to see benefits. For example, herbs like Rhodiola Rosea may have quicker effects on mental fatigue, with some studies showing benefits in as little as a week, while other adaptogens like Ashwagandha may take several weeks to demonstrate notable stress reduction effects.
Dosage
The dose of the adaptogen can also influence how quickly results are noticed. Higher doses may produce effects more quickly than lower doses, but this should be balanced with the potential for increased risk of side effects.
Individual’s Health Status
The health status of the individual can also play a role. Those with higher levels of chronic stress or other health conditions may take longer to notice the effects, as the body may need more time to restore balance.
Lifestyle Factors
A healthy lifestyle, including a balanced diet, regular exercise, and adequate sleep, can enhance the effectiveness of adaptogens and may help individuals see benefits more quickly.
In general, it’s important to remember that adaptogens work subtly over time to help the body better respond to stress. Therefore, patience is key when starting an adaptogen regimen. It’s also crucial to consult with a healthcare provider before starting any new supplement regimen, including adaptogens, to ensure it’s safe and appropriate for your specific needs.
Coaching Toolbox: What Health and Fitness Coaches Need to Know About Adaptogens
As a health and fitness coach, understanding the potential benefits and applications of adaptogens can be a valuable addition to your coaching toolbox. It is crucial, however, to remember the limitations of your role and ensure that you are providing advice within your scope of practice.
- Educate on the Concept of Adaptogens: When clients are curious about adaptogens, you can discuss with them how these natural substances might support the body’s ability to handle stress. Clients may hear about adaptogens in popular health media and having an informed perspective can allow you to provide them with evidence-based information.
- Support Holistic Well-being: While coaches often focus on physical exercise and dietary advice, understanding the potential stress-modulating effects of adaptogens can enable a more holistic approach. This knowledge underscores the importance of managing mental and emotional stress as part of a comprehensive health and fitness strategy.
- Encourage Consultation with Healthcare Providers: As a coach, it is crucial to remind clients that while adaptogens can offer numerous health benefits, they are not a substitute for medical treatment. Clients should always consult with their healthcare provider before starting any new supplement regimen, including adaptogens. This is particularly important for clients with underlying health conditions, those who are pregnant or breastfeeding, and those who are taking other medications.
- Stay Informed: The field of adaptogen research is rapidly evolving. Continuing education about the latest research can help you maintain an informed perspective and provide the best possible guidance to your clients.
- Respect Your Scope of Practice: Finally, it is essential to remember that unless you have additional certifications or credentials, it is generally outside of the scope of practice of a health and fitness coach to recommend specific supplements, including adaptogens. Instead, coaches can provide information and encourage clients to discuss these options with their healthcare provider.
Main Takeaways
In this exploration of adaptogens, we have traversed from ancient times to the present day, uncovering the nature, origin, and potential benefits offered by these remarkable substances. From ashwagandha to turmeric, we have seen how these natural compounds, recognized for their adaptogenic properties, can potentially aid the body in managing stress, supporting the immune system, enhancing cognitive function, and promoting overall well-being.
We have also navigated the precautions that must be taken when incorporating adaptogens into one’s routine, emphasizing the importance of professional consultation, understanding potential side effects, and recognizing that the benefits of adaptogens might take time to manifest. Furthermore, we have illuminated the distinction between adaptogenic botanicals in their natural form and those in supplements, highlighting the need for careful consideration when choosing between the two.
Health and fitness coaches should feel better equipped to handle questions and guide discussions about adaptogens, even though it is generally outside their scope of practice to recommend specific supplements. This knowledge forms an essential part of the coaching toolbox, facilitating holistic advice to clients and fostering an atmosphere of informed decision-making.
Ultimately, the world of adaptogens is a testament to nature’s profound potential to enhance health and resilience. As the research in this field continues to unfold, the promise of adaptogens only shines brighter, opening new avenues for natural, holistic wellness strategies that honor the body’s innate capability to adapt and thrive.
References
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7756641/
- https://journals.sagepub.com/doi/10.4103/0253-7176.106022
- https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-12-70
- https://www.mdpi.com/1424-8247/3/1/188
- https://www.sciencedirect.com/science/article/abs/pii/S094471131000036X?via%3Dihub
- https://journals.sagepub.com/doi/10.1177/0269881106061516
- https://www.mdpi.com/1424-8247/3/1/188
- https://www.annualreviews.org/doi/10.1146/annurev.pa.09.040169.002223
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6035378/
- https://www.mdpi.com/1999-4923/15/4/1057
- https://journals.sagepub.com/doi/10.4103/0253-7176.106022
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4296439/
- https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-12-70
- https://www.sciencedirect.com/science/article/abs/pii/S037887410800216X?via%3Dihub
- https://journals.sagepub.com/doi/10.1177/0269881106061516
- https://www.worldscientific.com/doi/abs/10.1142/S0192415X16500014
- https://pubmed.ncbi.nlm.nih.gov/27408987/
- https://www.tandfonline.com/doi/full/10.3109/13697137.2014.929649
- https://www.airitilibrary.com/Publication/alDetailedMesh?DocID=03044920-201004-201006110036-201006110036-105-111
- https://pubmed.ncbi.nlm.nih.gov/22593926/
- https://www.sciencedirect.com/science/article/abs/pii/S2222180813600493?via%3Dihub
- https://onlinelibrary.wiley.com/doi/10.1002/ptr.2362
- https://onlinelibrary.wiley.com/doi/10.1002/ptr.5325
- https://www.sciencedirect.com/science/article/abs/pii/S0378874107006411?via%3Dihub
- https://www.liebertpub.com/doi/10.1089/acm.2008.0018
- https://pubmed.ncbi.nlm.nih.gov/19594223/
- https://www.sciencedirect.com/science/article/abs/pii/S037887410400457X?via%3Dihub
- https://pubmed.ncbi.nlm.nih.gov/2553871/
- https://pubmed.ncbi.nlm.nih.gov/22593926/
- https://www.mdpi.com/1422-0067/17/11/1810
- https://pubmed.ncbi.nlm.nih.gov/27616182/
- https://pubmed.ncbi.nlm.nih.gov/19594223/
- https://journals.sagepub.com/doi/10.4103/0253-7176.106022
- https://www.dovepress.com/multicenter-open-label-exploratory-clinical-trial-with-rhodiola-rosea–peer-reviewed-fulltext-article-NDT
- https://www.liebertpub.com/doi/10.1089/acm.2011.0367
- https://www.tandfonline.com/doi/full/10.3109/13697137.2014.929649
- https://pubmed.ncbi.nlm.nih.gov/22593926/
- https://www.sciencedirect.com/science/article/abs/pii/S037887410400457X?via%3Dihub
- https://pubmed.ncbi.nlm.nih.gov/20384847/
- https://www.frontiersin.org/articles/10.3389/fphys.2018.01047/full
- https://www.sciencedirect.com/science/article/pii/S0028390811003054?via%3Dihub
- https://www.sciencedirect.com/science/article/pii/S2352289516300509?via%3Dihub
- https://www.sciencedirect.com/science/article/abs/pii/S2222180812602072
- https://www.semanticscholar.org/paper/Ginseng%3A-A-panacea-linking-East-Asia-and-North-Choi-Wong/c3e6358f429312e065493a4a1fcc76005155bb15
- https://pubmed.ncbi.nlm.nih.gov/10956379/
- https://www.sciencedirect.com/science/article/abs/pii/S0944711310002680?via%3Dihub
- https://link.springer.com/article/10.1208/s12248-009-9146-8
- https://www.mdpi.com/1424-8247/3/1/188
- https://www.aafp.org/pubs/afp/issues/2003/1015/p1539.html
- https://www.mdpi.com/1424-8247/3/1/188
- https://www.sciencedirect.com/science/article/abs/pii/S2222180812602072
- https://journals.sagepub.com/doi/10.4103/0253-7176.106022
- https://www.sciencedirect.com/science/article/abs/pii/S0944711300800550?via%3Dihub
- https://www.sciencedirect.com/science/article/abs/pii/S0944711304700586?via%3Dihub